In most developed countries, along with the cytological method, testing for human papillomavirus infection (PCR test, Digene-test)is also widely used. Although the principles of observation for negative results have beencompletelyestablished, clear instructionshave not been formulated in the high-risk groups (CIN II and CIN III), and in each case, they are based on clinical data and the results of a histological examination. Colposcopy, cytological examination and biopsy of the cervix allow identifying high-risk groups requiring surgical intervention and subsequent postoperative observation. The above data indicate the existence of shortcomings in the program for early diagnosis of cervical cancer and the need to study the possibilities of its expansion. In the Russian Federation, the 10-year increase in morbidity is 24.28%, and the increase in cervical cancer cases in young women under the age of 29 for the same period is about 150% in the UK, over the past 10 years, a tendency for an increase (about 4%)in age-specific morbidity has been observed. Thus, the use of screening in the United States has led to more than 50% reduction in mortality from cervical cancer, and the annual increase in morbidity is about 0.7%. However, it is still impossible to discuss the stabilization of the increase, especially if we take into account that more than 80% of cervical cancer cases occur in developing countries, where targeted screening isabsent or poorly organized. The widespread use of a whole range of diagnostic procedures, among which cytological examination of the cervical smear remains the leading one, allowed significantly reducing the incidence in developed countries. Abstract: Despite the actively applied screening and certain successes in the diagnosis and treatment of cervical cancer (CC), the morbidity in many regions of the world remains high.
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